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Five ways to examine and diagnose common chronic allergic asthma

Asthma is one of the most common chronic diseases in the world. Nearly 300 million people worldwide suffer from asthma, including nearly 30 million in China. Relevant studies have found that the incidence of asthma in China is as high as 1.24% asthma symptoms in children. Therefore, how to prevent and treat asthma well has become an imminent problem.

01 The pathogenesis of asthma is not yet clear, but the current academic community mainly believes that the pathogenesis of asthma can be divided into two types, and the two types interact to cause asthma

1. Airway immune inflammation theory

It is believed that the pathogenesis of asthma is mainly caused by chronic inflammation and response of the airway. Patients exposed to or inhaled large amounts of exogenous allergens in their daily lives. This, in turn, leads to immune activation. At the same time, the activation of immune function will shrink the gas to the plane with a large number of active mediators, which will increase the mucus and may lead to inflammatory cell infiltration of the airway asthma symptoms in children checklist, thus triggering asthma pathophysiology of asthma made easy.

According to this theory, asthma can be divided into early-onset delayed asthma and bi-directional asthma response according to the time of inhalation of red-sensitive factors. Early-onset asthma is a small boat that is sensitized by inhalation and occurs immediately after inhalation. Meanwhile, it can gradually return to normal within two hours, while the persistent and late onset asthma can be resolved effectively for several days after inhalation.

At the same time, this theory also believes that long-term inflammatory response may cause damage to airway epithelium, exposing the nerve endings of the subepithelium and other related factors. Tissue may cause an increase in airway response basic pathophysiology of asthma. The symptoms that make asthma appear again are significantly worse.

2. Neuromodulation

The theory is that neurotransmitters are one of the main causes of asthma. The bronchi are mainly innervated by the autonomic nerves. However, once a large number of nerve stimulation occurs in patients, it may lead to abnormal functional response of the bronchial tube and then cause vascular dilation and other related symptoms. It’s not a response triggered by the immune system, but it’s very similar to inflammation, also known as neuronal inflammation and neuroinflammation, which can trigger asthma attacks.

02 Asthma may be caused by the following factors and needs special attention in daily life asthma physiology and pathophysiology.

1. Environmental factors

Environmental factors, as long as they mainly refer to people living in the environment, may cause allergic reactions in the human body related allergens such as cockroaches, pollen, paint, fish, shrimp, protein and other related substances. The main mechanism of asthma is inflammation of the airways caused by allergies, so it is important to stay away from allergens in daily life.

In fact, most asthma is caused by patients’ allergies to pollen and other related substances. It is particularly important to wear a mask when going out to avoid contact with allergy sources and to identify the sources of one’s own allergies in daily life asthma etiology and pathophysiology. Doing so can help people avoid asthma and allergic diseases.

2. Genetic factors

Although for now. It is not clear which genes are responsible for asthma, but it is clear that asthma is caused by a complex set of polycrystalline compounds. It runs in families, meaning the closer two people are to each other, the more likely they are to develop asthma.

Asthma related genes can only control whether asthma is susceptible or not, so it is particularly important to control and protect asthma in daily life. Especially for those families with asthma, people with asthma need to protect themselves from asthma in their daily life.

3, obesity

Although not yet clear how obesity will lead to asthma, but the study suggests that obese people suffer from asthma risk is much higher than other normal person, weight control to avoid obesity is particularly important pathophysiology asthma explained, and obesity is also most important inducing factors, disease related diseases such as diabetes, high blood pressure, heart disease. So in the daily life should pay special attention to control weight, avoid obesity, and do a proper amount of exercise.

1. Sputum examination

Many asthmatics may experience sputum abnormalities and other related symptoms, such as increased eosinophil counts in their sputum, which may contribute to asthma. The main principle of this test is to determine whether there is asthma by counting the number of acid granulocytes in Tan Yan. If there is asthma, there may be airway inflammation pathophysiology of asthma made easy, which triggers the activation of the immune system in the body and makes the eosinophil count high.

At the same time, sputum examination can also help to determine whether respiratory dyspnea symptoms are caused by infection, so as to help doctors better judge whether asthma related glucocorticoids should be used. If it is caused by infection, further diagnosis and treatment can be carried out to better control the disease.

2. Lung function test

Asthma is likely to lead to abnormal lung function, mainly the occurrence of diseases related to injection ventilation dysfunction. Therefore, it is very important for asthma patients to have relevant pulmonary function examination pathophysiology of chronic asthma, including but not limited to ventilation function examination, bronchial diastolic test and other relevant examinations. That would better identify changes in lung function that could lead to a diagnosis of asthma.

3. X-ray examination

X-rays are also necessary for asthmatics to see the structural changes taking place in the lungs. X-rays that pass through denser parts of the body, such as bones, appear white, but pass through denser parts of the body, such as fluid in the abdominal cavity, and become black. People with asthma are more likely to experience changes in the brightness of both lungs and to experience hyperventilation.

4. IgE examination

This test can obviously determine whether there is an allergic reaction in the body pathophysiology of asthma in adults, thus helping to determine whether asthma is caused by allergies. Meanwhile, it should be noted that peripheral blood test is helpful for the diagnosis of asthma, but the blood test is not of great value for the diagnosis of asthma, and can only serve as a basis for drugs.

5. Arterial blood gas analysis

Severe asthma is likely to lead to hypoxia, which decreases the partial pressure of carbon dioxide in the blood and increases the pH value, which is reflected in respiratory acidosis. In order to prevent respiratory acidosis, arterial blood gas analysis is carried out for severe patients for better treatment.

6. Determination of nitric oxide

Nitric oxide is mainly an important hormone that leads to the dilation of blood vessels in the body. Therefore, the measurement of nitric oxide can be used to evaluate the control level of airway inflammation and asthma, so as to judge the response of patients to inhaled hormone treatment, and thus help patients to better determine the next treatment.

Conclusion: Asthma is a disease that many children will change at present, which is mainly related to five external allergens. Therefore, how to better diagnose the external allergens and diagnose asthma earlier is of great significance for treating asthma and preventing related diseases caused by asthma. People who work night shifts are a third more likely to develop asthma than those who work a nine-to-five job, a study has found.

Researchers from Manchester found that moderate to severe asthma was more common among shift workers, especially those who worked long night shifts.According to the team, the impact could be “profound”, with about a fifth of the workforce working full-time or on shifts at night.Past research has shown that shift work can cause the body’s internal clock to get out of sync with the daily circadian cycle. Experts have concluded that this is linked to an increased risk of metabolic disorders, cardiovascular disease and cancer.

Asthma symptoms, such as wheezing, vary widely and vary with the time of day or night.

With this in mind, the researchers wanted to find out whether shift work was also associated with an increased risk of asthma or an increased severity of asthma.They also set out to explore the impact of a person’s genetic predisposition to asthma and their “chronotype” — whether their biological clock is more inclined to be an “early bird” or a “late sleeper” pathophysiology of acute asthma exacerbation.The team analysed health, lifestyle and employment data collected from more than 286,000 UK workers aged between 37 and 72 between 2007 and 2010.

Of those surveyed, 83 per cent worked regular office hours, while the rest worked night shifts – about half of whom worked occasional or permanent shifts.The team noted that shift workers were more likely to be men, smokers and people from urban or poor areas than those who work a 9-to-5 job.Shift workers typically drink less alcohol, sleep less and work longer hours.

Night workers seem to be more likely to be late sleepers and to be in poor health, either in service jobs or in processing, factory or machine operations.By contrast, those who work regular hours tend to have more managerial positions.About 5 percent of the study participants had asthma, and nearly 2 percent had moderate to severe symptoms.The researchers compared the incidence of asthma diagnoses, lung conditions, and asthma symptoms among office workers and shift workers.The researchers found that when other risk factors, such as age and gender, were taken into account, long-term night shift workers were 36% more likely to have moderate to severe asthma than office workers.

Similarly, shift workers were 11 to 18 per cent more likely to have wheezing or respiratory whistling symptoms, while workers who worked occasional or long-term night shifts were 20 per cent more likely to have poor lung function.The team also found that so-called “extreme chronotypes” — those who were definitely early birds or those who went to bed late — were significantly more likely to have asthma.

In addition, early-bird types, whether they worked night shifts or irregular shifts, were 55 percent more likely to have moderate to severe asthma, regardless of genetic predisposition.The researchers cautioned that because their study was observational, they have not yet determined the exact reason why night shift workers are at greater risk for asthma.”It makes sense that a circadian rhythm disorder contributes to the development of asthma acute and chronic asthma pathophysiology.” “Said Hannah Durrington, an author and a respiratory expert at the University of Manchester.

“Interestingly, chronotype does change with age, with later puberty and earlier adulthood, suggesting that older people may have a harder time adapting to night work than younger people.””The public health implications of our findings could be profound, as shift work and asthma are common in industrialized countries.”

“Around the world 339 million people suffer from asthma, costing over £1 billion in healthcare costs in the UK alone.”She noted that there are no specific national clinical guidelines on how shift workers manage asthma. The researchers suggest that employers should consider adjusting shift work schedules to best suit individual timelines.Asthma is one of the common respiratory diseases. Its main characteristics are sudden stop and repeated attacks. It is also difficult to treat. Once asthma attacks, if relevant emergency measures are not taken in time, it will bring certain damage to the health of patients, and seriously endanger the safety of patients’ lives. So asthma attacks are very dangerous, these first aid measures to pay attention to grasp well.

What are the first aid measures for asthma?

1. Protect air circulation

When asthma patients have an attack, it is necessary to promptly move the patient to a place with good ventilation environment, preferably a place with relatively fresh air around, so as to avoid irritating the patient. If the surrounding air is too cloudy, or has the irritant gas, easy to irritate the patient’s respiratory tract, aggravates the attack of asthma. Therefore, when asthma patients have an attack, they should pay attention to timely move to a place with a better environment, so as to relieve the disease and avoid repeated attacks.

2. Use aerosol first aid

For asthma patients, they usually carry an aerosol with them. If the patient has an attack, they should use the aerosol in a timely manner, which can effectively alleviate the patient’s condition. Therefore, as asthma patients should pay attention to carry medicines with them, because asthma belongs to a sudden disease, when asthma suddenly attacks, relevant drugs can be used to give first aid in a timely manner.

3. Swallow properly

When a patient has asthma attack, if he/she does not carry first-aid medicine with him/her, he/she can take the swallowing action appropriately to relieve the symptoms. Repeat the swallowing action several times, which can properly relieve the asthma attack.When asthma patients attack, if there is no experience in first aid or the patient’s condition is relatively serious, we should pay attention to call the emergency center for help in time. Asthma patients should pay attention to take relevant measures as soon as possible, most of the time is life, if the treatment is not timely, it will lead to serious illness, and even life risk.

Asthma is a tricky respiratory disease to treat, and is prone to recurring episodes, many times due to the stimulation of certain factors will suddenly attack. Once the outbreak if not timely first aid measures, to the patient’s health and life safety will bring a greater risk.

Especially acute asthma attacks will lead to death, generally in the outbreak of acute asthma, the patient’s nose and eyelids will appear itching and tears and other symptoms, this time can be timely medication to alleviate. People with asthma at home should pay attention to learn the above emergency measures for asthma attacks, which can play a certain role in relieving patients when they have attacks.

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